Pathogenesis
Across
- 1. Enhances elongation of rete-pegs,Stimulates apical proliferation of junctional epithelium and pocket formation.
- 4. Synthesized from the cell wall(de nevo)as result of mast cell activation
- 5. killing by lysosomal acid hydrolases including proteases.
- 6. cells professional antigen presenting cells react with antigens which are in the process of penetrating the oral epithelium initiating an early immune response
- 7. the bacteria are trapped within it.
- 8. Cells with CD8 are 1/3 of the cells
- 11. Appears during healing of tissues as it shuts down the immune response.
- 14. part of the innate immunity that starts with complement c3 activated by the LPS in cell wall of G-ve bacteria
- 16. lymphocyte activating molecules
- 19. part of the adaptive immunity that starts with complement C1 activated by antigen antibody complex
- 21. results from the breakdown of Arachidonic acid via the cyclo oxygenase pathway.
- 22. via various receptors on cell surface of phagocytes.
- 23. one of the acute phase proteins that coats mannose residues on surface of G+ve and G-ve bacterial cell wall
- 25. generation of ROS
- 26. Acts on PMNs and MQ to release MMPs
- 27. Inflammatory mediators released from preformed granules in the mast cell.
Down
- 2. one of the acute phase proteins that that coats LPS of G –ve bacteria
- 3. it is formed as result of fusion of lysosomes with PMNs.
- 9. secretes mainly IL-2 and TNF to stimulate the function of Tc cells.
- 10. killing by oxidants that oxidize cell membrane of bacteria resulting in their death
- 12. 3a, C4a, C5a
- 13. by extensions of the cytoplasm and cell membrane called pseudopodia around it.
- 15. Acts with IL-1 in a synergistic manner to release acute phase proteins from the liver,Stimulate osteoclasts formation.
- 17. structure of periodontal pathogens that resists opsonization thus evade phagocytic cells
- 18. ALL three complement pathways end up by it's formation
- 20. secretes IL-4, IL-5, IL-6 that stimulate B-cells to turn to plasma cells.
- 24. Appears during healing of tissues and it increases ECM production.