Pathophysiology of MI

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Across
  1. 2. inactive precursor of proteolytic enzyme
  2. 3. inhibitor of NOS
  3. 5. reduces the bioavailability of nitric oxide
  4. 7. vascular cell adhesion molecule 1
  5. 9. product of the mavelonate pathway
  6. 11. factor II
  7. 12. describes platelets that have not been activated
  8. 14. reduces platelet aggregation by inhibiting PDE, blocking adenosine uptake into red cells, and reduces TXA2 synthesis
  9. 17. inhibits cyclooxygenase
  10. 18. clotting pathway initiated by tissue damage
  11. 19. monocyte chemotactic protein 1
  12. 20. two thirds of the body's cholesterol is synthesised here
  13. 22. clotting pathway initiated by contact with glass
  14. 23. activates guanylyl cyclase, which converts GTP to cyclic GMP
Down
  1. 1. a natural anticoagulant
  2. 4. substrate for nitric oxide synthase
  3. 6. maintains platelets inactive state by releasing PGI2 and NO
  4. 8. cGMP can produce this effect in blood vessels
  5. 9. the principal matrix protein that interacts with platelets
  6. 10. P2X antagonist that inhibits ADP-induced platelet aggregation
  7. 13. converts soluble fibrinogen to insoluble strands of fibrin
  8. 15. end product of the coagulation pathway
  9. 16. inhibit the rate-limiting enzyme for cholesterol biosynthesis
  10. 21. bridging molecule