Pathophysiology of MI

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Across
  1. 3. inactive precursor of proteolytic enzyme
  2. 4. inhibit the rate-limiting enzyme for cholesterol biosynthesis
  3. 7. maintains platelets inactive state by releasing PGI2 and NO
  4. 9. factor II
  5. 10. vascular cell adhesion molecule 1
  6. 13. cGMP can produce this effect in blood vessels
  7. 15. inhibitor of NOS
  8. 16. product of the mavelonate pathway
  9. 18. substrate for nitric oxide synthase
  10. 19. reduces the bioavailability of nitric oxide
  11. 20. a natural anticoagulant
  12. 22. clotting pathway initiated by tissue damage
  13. 23. end product of the coagulation pathway
Down
  1. 1. describes platelets that have not been activated
  2. 2. two thirds of the body's cholesterol is synthesised here
  3. 5. converts soluble fibrinogen to insoluble strands of fibrin
  4. 6. reduces platelet aggregation by inhibiting PDE, blocking adenosine uptake into red cells, and reduces TXA2 synthesis
  5. 8. P2X antagonist that inhibits ADP-induced platelet aggregation
  6. 11. the principal matrix protein that interacts with platelets
  7. 12. monocyte chemotactic protein 1
  8. 13. bridging molecule
  9. 14. clotting pathway initiated by contact with glass
  10. 17. inhibits cyclooxygenase
  11. 21. activates guanylyl cyclase, which converts GTP to cyclic GMP