Pediatric Oncology Crossword

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Across
  1. 2. Abnormal white pupillary reflex replacing the normal red reflex, classically seen in retinoblastoma.
  2. 4. Most common malignant renal tumor of childhood, strongly associated with WT1 mutations and WAGR syndrome.
  3. 5. Pediatric glial tumor arising from the lining of the cerebral ventricles (often the fourth ventricle) and spinal canal, showing perivascular pseudorosettes.
  4. 7. Febrile ____________: an oncologic emergency defined by fever and an ANC < 500/µL requiring immediate empiric IV antibiotics.
  5. 9. PI3K-alpha inhibitor used in targeted therapy for PIK3CA-related overgrowth spectrum (PROS) and vascular malformations.
  6. 11. Surgical central venous access device implanted under the skin, essential for pediatric chemotherapy administration.
  7. 13. Pathognomonic translocation t(9;22) resulting in the BCR-ABL1 fusion gene, famously known as the ____________ chromosome.
  8. 14. "____________ eyes" (periorbital ecchymosis), a classic sign of orbital metastasis in neuroblastoma.
  9. 15. Oral MEK1/2 inhibitor used in BRAF V600E-mutated pediatric low-grade gliomas and vascular anomalies.
  10. 17. Proto-oncogene whose amplification is the single most important adverse genetic prognostic factor in neuroblastoma.
  11. 19. Targeted MEK1/2 inhibitor used to treat inoperable plexiform neurofibromas in NF1 patients.
  12. 22. Interdisciplinary field focused on preserving reproductive potential (e.g., ovarian tissue cryopreservation) prior to gonadotoxic pediatric therapy.
  13. 25. Benign vascular tumor of infancy that undergoes rapid proliferation followed by spontaneous involution; first-line treatment is propranolol.
  14. 27. Most common pediatric hematologic malignancy, peaking between ages 2 and 5.
  15. 28. Definitive tissue sampling procedure required to establish a histopathologic and molecular cancer diagnosis before initiating therapy.
  16. 31. Reed-Sternberg cells ("owl-eye" appearance) are pathognomonic for this lymphoma.
  17. 33. Anthracycline chemotherapy agent requiring cumulative dose monitoring due to irreversible cardiotoxicity.
  18. 34. The most common extracranial solid tumor in infants, arising from neural crest cells; often associated with MYCN amplification.
  19. 35. Benign suprasellar tumor derived from Rathke's pouch remnants, causing bitemporal hemianopsia and endocrine dysfunction.
  20. 37. Aggressive B-cell non-Hodgkin lymphoma characterized by a "starry-sky" histologic appearance and t(8;14) MYC translocation.
  21. 38. Most common primary malignant liver tumor in young children, strongly associated with markedly elevated serum AFP and Beckwith-Wiedemann syndrome.
  22. 39. ____________ cell histiocytosis: clonal proliferation of dendritic-like cells featuring Birbeck granules ("tennis rackets") on electron microscopy.
Down
  1. 1. Recombinant urate oxidase enzyme used to prevent and treat acute tumor lysis syndrome.
  2. 2. Autosomal dominant cancer predisposition syndrome caused by germline TP53 mutations (2 words, no hyphen).
  3. 3. Most common primary malignant bone tumor in adolescents, classically showing a "sunburst" pattern and Codman triangle on X-ray.
  4. 6. Most common malignant pediatric brain tumor, typically arising in the cerebellar vermis and prone to CSF "drop metastases".
  5. 8. The classic "cat's eye" reflex (leukocoria) is the hallmark presenting sign of this pediatric ocular malignancy.
  6. 10. Non-selective beta-blocker used as first-line medical therapy for complicated infantile hemangiomas.
  7. 12. Vinca alkaloid microtubule inhibitor causing dose-limiting peripheral neuropathy and constipation; fatal if given intrathecally.
  8. 16. Pilocytic ____________: the most common benign pediatric brain tumor, classically cystic with a mural nodule and Rosenthal fibers.
  9. 18. Alkylating chemotherapy agent associated with hemorrhagic cystitis and long-term gonadal toxicity.
  10. 20. Uroprotective agent co-administered with cyclophosphamide or ifosfamide to prevent hemorrhagic cystitis.
  11. 21. Gold-standard imaging modality for staging pediatric CNS tumors without ionizing radiation.
  12. 23. Most common soft-tissue sarcoma in children, arising from skeletal muscle progenitors; often presents in the head/neck or genitourinary tract.
  13. 24. Antimetabolite folic acid antagonist used in high doses for ALL and osteosarcoma; requires leucovorin rescue.
  14. 26. Malignant bone tumor classically showing an "onion-skin" periosteal reaction on X-ray and a t(11;22) translocation.
  15. 29. mTOR inhibitor widely used off-label in complex lymphatic and venous vascular malformations.
  16. 30. Germ cell tumor containing mature or immature tissues derived from all three embryonic germ layers.
  17. 32. Anti-GD2 monoclonal antibody used in maintenance immunotherapy for high-risk neuroblastoma.
  18. 36. First-generation tyrosine kinase inhibitor targeting BCR-ABL1 in Philadelphia chromosome-positive ALL and CML.