Pharmacodynamics quizz

4. The acute or rapid development of drug tolerance following repeated doses administered at short intervals.
5. A cardiac drug with a very narrow therapeutic index and a large volume of distribution that is prone to cumulative toxicity.
8. A drug that possesses both affinity and intrinsic activity to bind to a receptor and produce a pharmacological response.
10. A severe neonatal brain condition caused by the displacement of bilirubin from albumin binding sites by sulfonamides given late in pregnancy.
11. The capability or binding capacity of a drug to form a complex with its specific receptor.
14. When two or more drugs are given simultaneously and their combined effect is significantly greater than the sum of their individual effects.
15. A pharmacologically inactive compound whose name means "I please," used to treat subjective symptoms via psychological effects.
16. The requirement of an increased drug dose to produce the same pharmacological response after repeated administration.
19. A decrease in the total number of receptors due to continuous, intense desensitization by an agonist.
20. An increase in the total number of cell receptors, often caused by the prolonged block or deprivation of an agonist by an antagonist.

1. A chemical mechanism by which heavy metals are bound and eliminated from the body.
2. The physical mechanism utilized by activated charcoal to bind unabsorbed drug molecules on its large surface area.
3. A competitive opioid receptor antagonist used to reverse morphine overdose or block placebo-induced analgesia.
6. An irreversible proton pump inhibitor classified as a "hit-and-run" drug because its action outlasts its presence in plasma.
7. The enhancement of the action of one drug by the addition of another, where the combined effect is greater than individual parts (e.g., Levodopa + Carbidopa).
9. The physical process/action by which magnesium sulphate retains fluid to act as an osmotic purgative.
12. A drug that displays receptor affinity but lacks intrinsic activity ($E=0$), thereby blocking an agonist's effects.
13. A type of antagonism where the antagonist binds to the same active site as the agonist and can be overcome by increasing the agonist concentration.
17. Also known as intrinsic activity; the ability of a drug to produce a pharmacological response after binding to a receptor.
18. A specific antagonist that binds to the $GABA_A$ receptor complex to reverse a benzodiazepine overdose.