Pharmacogenomic terminology

3. A collection of genetic variants, such as SNPs, that always travel together (are inherited together) on the same individual allele
6. An unintended, harmful reaction to medicines
7. metaboliser Two non-functional alleles and therefore have little to no enzyme activity
10. A variant that has two or more alleles and is present at a frequency of at least 1% of the population
11. When two different alleles are present on the chromosome pair
13. gene A gene predicted to be associated with a particular trait e.g disease, adverse reaction to a drug
15. The basic physical unit of inheritance
17. well know anticoagulant that causes severe side affects in certain individuals

1. An individual’s collection of genes
2. A precursor (forerunner) of a drug needs to undergo chemical conversion by metabolic processes before becoming an active pharmacological agent
4. The biochemical and physiological effects of drugs, particularly those that define the drugs mechanism of action on the body
5. A single nucleotide locus with two or more naturally occurring alleles defined by a single base pair substitution
8. Part of the genome formed by DNA sequences that encode genes
9. P450 A group of enzymes involved in drug metabolism and found in high levels in the liver
12. metaboliser Two normally functioning alleles and therefore have normal enzyme activity
14. HIV drug for which all patients undergo a genetic test prior to administration
16. A study to assess common genetic variations across the entire genome of a large population of individuals in order to study whether any of the investigated variations is associated with a phenotype of interest