Pharmacology and Toxicology

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Across
  1. 2. Teratogenesis or _______ defect development may be an toxic effect of some drugs
  2. 4. The study of chemicals on biological systems
  3. 5. Dose or concentration of drug that is effective
  4. 6. Interacts with receptor to block the action of an agonist
  5. 7. Lethal dose and _________ dose are both used in determining a drug's safety margin
  6. 9. Type of drug administration that would have 100% bioavailability
  7. 13. Any substance that brings about a change in biological function
  8. 14. Acronym for determining drug disposition
  9. 15. Two ways for the body to limit a drug's effect include metabolism and _________
  10. 16. The organ responsible for the majority of drug metabolism
Down
  1. 1. Intensity of molecular or cellular change that results from the drug-receptor interaction
  2. 3. _______ index is intended to indicate the margin of safety of a drug
  3. 5. This phase is primarily concerned with safety during drug development
  4. 6. Describes the passage of a drug from its site of administration into the plasma
  5. 8. The study of adverse effect of chemicals on living organisms
  6. 10. Drug receptors can be intra- or _______cellular
  7. 11. Specific macromolecule with which a drug may interact to exert its effects
  8. 12. Mutual attraction between drug and receptor
  9. 13. The amount of chemical being administered