Pharmacology I Crossword Puzzle

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Across
  1. 3. The study of the influence of genetics on drug response
  2. 7. A fast decrease of the effect caused by the ligand after continuous or repeated drug administration
  3. 8. A physiological response to a new situation or conflicts that can become a pathological problem if it is too intense or long lasting
  4. 9. Molecules able to bind to a receptor but not able to trigger any effect
  5. 10. A chronic disorder characterized by recurrent seizures caused by sudden excessive electrical discharges in a group of neurons
  6. 12. Type of interaction that modifies the action mechanism of the drug without varying its plasma concentration
  7. 15. Endogenous opioid mediators that regulate pain, respiration, body temperature, and stress responses
  8. 17. The science and activities relating to the detection, assessment, understanding and prevention of adverse effects
  9. 21. An unpleasant sensory and emotional experience associated with actual or potential tissue damage
  10. 22. An atypical antipsychotic that treats vertigo with low doses and is used as an antipsychotic at high doses
  11. 23. A functional disturbance due to injuries in motor pathways which leads to severe muscle spasms
  12. 24. Enzymes that contain an extracellular domain that binds ligands, a transmembrane domain and an intracellular domain involved in phosphorylation reactions
  13. 25. A drug used as a prophylactic measure for reducing the number of mania or depression crises, which has a narrow therapeutic window
  14. 26. Process in which the resulting action is greater than the sum of the individual actions because both drugs act on different receptors
Down
  1. 1. Tendency of a drug, once bound, to activate the receptor and cause a response or maximum effect
  2. 2. A dopamine precursor used to activate dopamine receptors directly
  3. 4. A non-competitive antagonist of the NMDA receptors that prevents excitotoxicity
  4. 5. The fraction of an administered dose of unchanged drug that reaches the systemic circulation
  5. 6. Any chemical substance that produces changes in living organisms
  6. 11. A pure antagonist used to combat morphine intoxication and reverse respiratory depression immediately
  7. 13. A series of cascade reactions triggered by the ligand and receptor interaction that occur in the cytosol and are devoted to amplifying the response
  8. 14. Effects in the fetus that include any morphological, biochemical or behavioral side effect caused during fetal development
  9. 16. A mental disorder whose positive symptoms are produced by a dopamine hyperactivity in the mesolimbic and nigrostriatal systems
  10. 18. A special type of syndrome which mainly affects the emotional state of the patient, rather than disturbances of thought or cognition
  11. 19. An antagonist used for treating benzodiazepine intoxications by blocking their binding site
  12. 20. Tendency of a drug to bind to its receptors