pkcho07

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Across
  1. 2. First-order rate constant k governing decline in Cp
  2. 5. Shape of Cp-versus-time curve after a dose
  3. 7. PK parameters that are constant within a patient but vary across individuals
  4. 9. Pharmacokinetic values directly measured: Cl and Vd
  5. 11. Model assuming immediate distribution throughout Vd
  6. 14. Time Cp remains above MEC after an IV bolus
  7. 15. Cp₀ equal to SFD divided by Vd
  8. 16. Single rapid dose administered at time zero
  9. 19. Amount of drug in body immediately after IV bolus (SFD)
Down
  1. 1. Plasma plus rapidly perfused tissues where Cp is measured
  2. 3. Model-calculated Cp at any future time point
  3. 4. Values derived from primary parameters: k and t½
  4. 6. Assumption that entire dose enters body immediately
  5. 8. Determining Cl, Vd, and k from plasma concentration data
  6. 10. Time between repeated doses; trough measured at end of tau
  7. 12. Narrow therapeutic window drugs requiring monitoring (e.g., digoxin)
  8. 13. IV amount needed to instantly reach a desired Cp₀
  9. 17. Time required for Cp or amount to fall by 50 percent
  10. 18. Slope on ln(Cp) vs time plot used to compute k