pkchp06

1234567891011121314151617181920
Across
  1. 2. Portion of administered dose that contributes to plasma concentration
  2. 4. Tissues with delayed drug uptake such as fat and muscle
  3. 10. Parameter ka describing speed of drug absorption
  4. 14. Fraction of dose entering systemic circulation (F)
  5. 17. Relationship between dose and resulting plasma concentration profile
  6. 18. Delay before measurable absorption begins
  7. 19. Combining absorption, distribution, metabolism, and elimination in modeling
  8. 20. Tissues with fast drug uptake such as liver, kidney, and heart
Down
  1. 1. Model adding a second slowly equilibrating tissue group
  2. 3. Slowly perfused tissues that equilibrate more gradually
  3. 5. Early steep decline in Cp as drug enters poorly perfused tissues
  4. 6. Single straight line on ln(Cp) vs time plot characteristic of 1-cpt models
  5. 7. Curve with multiple phases reflecting distribution and elimination
  6. 8. Rapidly perfused tissues including plasma and eliminating organs
  7. 9. Model representing each tissue separately via mechanistic structure
  8. 11. Time required for 50% of drug in GI tract to be absorbed
  9. 12. Model assuming instantaneous distribution throughout body
  10. 13. Simplified representation grouping tissues by similar drug uptake rates
  11. 15. Later decline in Cp governed by drug elimination processes
  12. 16. Model with rapid central and slower peripheral distribution phases