Proteins & Amino Acids I

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Across
  1. 1. Tetrameric oxygen-transport protein that exhibits cooperative binding.
  2. 5. Pancreatic protease that cleaves peptide bonds within protein chains.
  3. 6. Enzyme that removes amino acids from the C-terminal end of peptides.
  4. 7. Molecule containing both positively and negatively charged functional groups.
  5. 9. Neurodegenerative disease associated with alpha-synuclein aggregation and Lewy bodies.
  6. 11. Severe nutritional deficiency characterized by marked wasting and loss of body fat.
  7. 12. Process in which genetic information in DNA is copied into messenger RNA.
  8. 16. Neurodegenerative disease associated with amyloid-beta plaques and tau tangles.
  9. 17. Level of protein structure characterized by alpha helices and beta sheets.
  10. 18. Nonpolar branched-chain amino acid that replaces glutamate in sickle hemoglobin.
  11. 20. Enzyme that removes amino acids from the N-terminal end of peptides.
  12. 25. Only standard amino acid without a chiral alpha carbon.
  13. 27. Inherited blood disorder caused by reduced synthesis of alpha or beta globin chains.
  14. 28. Essential branched-chain amino acid represented by the one-letter code L.
  15. 29. Polar amino acid with a hydroxyl group that can undergo phosphorylation.
  16. 32. Cyclic amino acid that restricts backbone flexibility and introduces turns.
  17. 33. Disruption of higher-order protein structure without usually breaking peptide bonds.
  18. 34. Sulfur-containing amino acid that forms disulfide bonds between protein regions.
  19. 37. Inactive enzyme precursor that helps prevent pancreatic autodigestion.
  20. 38. Intestinal epithelial cell responsible for absorbing amino acids and small peptides.
  21. 40. Protein-energy malnutrition characterized by edema and fatty liver.
  22. 41. Chemical reaction that forms a peptide bond with the release of water.
  23. 43. Level of protein structure involving the association of multiple polypeptide subunits.
  24. 45. Monomeric muscle protein that stores oxygen and lacks cooperative binding.
  25. 46. Intestinal cell membrane surface facing the intestinal lumen.
  26. 47. Amino acid containing an imidazole ring that can accept or donate protons near physiological pH.
  27. 48. Overall three-dimensional folding of a single polypeptide chain.
Down
  1. 2. Brush-border enzyme that converts trypsinogen into its active form.
  2. 3. Aromatic amino acid containing an indole ring that contributes to ultraviolet absorption.
  3. 4. Proton-linked intestinal transporter responsible for dipeptide and tripeptide uptake.
  4. 8. Intestinal cell membrane surface through which amino acids enter portal circulation.
  5. 10. Level of protein structure defined by the linear order of amino acids.
  6. 13. Genetic disorder in which defective CFTR function causes thick mucus secretions.
  7. 14. Aromatic amino acid containing a phenolic hydroxyl group involved in phosphorylation.
  8. 15. Cellular complex that degrades proteins marked for selective destruction.
  9. 19. Essential branched-chain amino acid represented by the one-letter code I.
  10. 21. Small protein that tags selected intracellular proteins for degradation.
  11. 22. Essential sulfur-containing amino acid with a thioether side chain.
  12. 23. Organelle containing hydrolytic enzymes that degrade cellular material.
  13. 24. Negatively charged amino acid replaced by valine at position six of the beta-globin chain in sickle cell disease.
  14. 26. Inherited neutral amino acid transport disorder that may cause pellagra-like symptoms.
  15. 30. Specific N-to-C arrangement of amino acids that determines peptide identity.
  16. 31. Process in which ribosomes use messenger RNA to synthesize a polypeptide.
  17. 32. Gastric enzyme that begins dietary protein digestion in the stomach.
  18. 34. Pancreatic endopeptidase that breaks internal peptide bonds.
  19. 35. Inherited renal transport disorder associated with cystine kidney stones.
  20. 36. Cellular process that delivers damaged organelles and protein aggregates for recycling.
  21. 39. Pancreatic enzyme that activates several other digestive enzyme precursors.
  22. 42. Protein that assists proper folding and helps prevent aggregation of new polypeptides.
  23. 44. Misfolded infectious protein capable of inducing abnormal folding in other proteins.