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2. The outermost layer of the skin.
6. A device that uses a low-level electrical current to enhance drug delivery through the skin.
7. A non-invasive method of drug administration.
9. The main disadvantage of TDDS due to the skin's low permeability.
10. A potent opioid used in a transdermal patch for chronic pain.
11. Tiny, painless needles that create channels in the skin to bypass the stratum corneum barrier.
14. An example of a common transdermal drug used for motion sickness.
15. A type of TDDS design where the drug is dissolved or dispersed directly within a polymeric adhesive.

1. The term for the steady, continuous release of a drug from a patch over time.
3. The adherence of the patch to the skin.
4. The absorption process of a drug moving from the patch, through the skin, and into the bloodstream.
5. The primary protective barrier of the skin.
8. A type of TDDS design where the drug is contained in a separate liquid or gel pocket, often with a rate-controlling membrane.
12. The ability of a substance to dissolve in fats or lipids.
13. A substance that increases the permeability of the skin to a drug.