Second Line of Defence Key Terms

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Across
  1. 5. Inititian, Vasodilation, Migration
  2. 9. Macrophage and dendritic cells become this after performing phagocytosis
  3. 10. Response of histamine that cuases increased blood flow to injury site and increases permeability to cells of the immune system
  4. 11. A process in which phagocytes consume and destroy foreign or dead materials in the body by engulfing it.
  5. 15. Complex sequence of events which occurs after the activation of complement proteins.
  6. 16. Phagocyte that links second and third lines of defence by becoming an APC
  7. 17. One of the three main features of the second line of defefeatures-specific One of the three main feature of the second line of defence
  8. 20. Abundant leucocyte that engages in phagocytosis as well as releasing cytokines to activate other immune cells
  9. 22. This is where complement proteins stick on the surface and encourages the phagocytes to recognise them as foreign. Similar to similar to a seasoning on a BBQ shape to make it look delicious,
  10. 23. A type of leukocyte responsible for releasing histamine
Down
  1. 1. Series of biochemical events that occur in the body as a result of infection and/or trauma.
  2. 2. Another name for white blood cells
  3. 3. Several different types of proteins found in the blood that opsonise, cause lysis and attract phagocytes to invading pathogens
  4. 4. Attack pathogens too large to be phagocytosed.
  5. 6. A type of leucocyte that are mobile and use phagocytosis to and engulf and destroy pathogens or damaged cells.
  6. 7. Membrane-bound organelle found within a phagocyte that contains digestive enzymes.
  7. 8. Cells that target abnormal cancerous cells and viarally infected cells and release chemicals that trigger apoptosis. Do not attack free-floating viral particles or cells infected by bacteria.
  8. 12. A cytokine released from virally infected cells and make surrounding cells less susceptible to the virus.
  9. 13. Temporary increase in body temperature. Many pathogens cannot survive.
  10. 14. One of the three main features of the second line of defence
  11. 15. Complement proteins gather near pathogen and attract phagocytes. Similar to finding a trail of breadcrumbs that draws the phagocyte to the pathogen.
  12. 18. One outcome of complement proteins. triggers lysis of a pathogen.
  13. 19. Substance degranulated from Mast Cells that plays a key role in inflammation
  14. 21. The product of an egulfed pathogen fusing with the lysosome of a phagocyte.