September Crossword

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Across
  1. 4. End of river, symbolising change (5)
  2. 6. Viral protein connects IV infusion (5) [cryptic]
  3. 8. Point of care coagulation test (3)
  4. 10. Partially dilate abnormal breathing (5) [cryptic]
  5. 11. Fixed performance oxygen delivery device , named for its driving principle (7)
  6. 12. Initially vascular, especially in neonates (4) [cryptic]
  7. 16. What Whipple removed, this drug replaces (5)
  8. 19. Banting + Best are celebrated for isolating this secretion (7)
  9. 21. Associated with primary ciliary dyskinesia in 1933 (5, 8)
  10. 22. Popular trend in cellular biochemistry (3) [cryptic]
  11. 23. A complex waveform (3) [cryptic]
  12. 25. Ebstein described triscupid valve descent, later associated with this teratogen (7)
  13. 27. Crepitations heard with ankylosing spondylitis (6)
  14. 29. Support to come around (4) [cryptic]
  15. 30. Coxiella causes this fever? (5)
Down
  1. 1. Mature lymphoid cells (6)
  2. 2. Duct; conduit; cylinder (4)
  3. 3. Alumni with specifc blood type maintain pressure (7) [cryptic]
  4. 4. Jervell-Lange-Nielsen syndrome associates this symptom with long QT(8)
  5. 5. Protective muscle innervated by cranial nerve VII (9)
  6. 7. Observed 'within glass' (2, 5)
  7. 9. One possible source of 'sweetbreads' (8)
  8. 13. Electron in formal triangle (7) [cryptic]
  9. 14. Seasonal factor deficiency causes bleeding (9) [cryptic]
  10. 15. Outward symptoms mask respiratory failure (4) [cryptic]
  11. 17. English county will lead you down wrong path? (4) [cryptic]
  12. 18. A brief glance at alveolar patency (4) [cryptic]
  13. 20. Fluid compartment named for Roman goddess (5)
  14. 22. Constitutional symptom with poor specificity (7)
  15. 24. Endovascular procedure for hepatic malignancy (4)
  16. 26. First party view of second party (3) [cryptic]
  17. 28. Named for characteristic rash, appearing as an animal bite (5)