Spectroscopic Structure and method validation

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Across
  1. 2. effect HPLC-MS interference from other compounds
  2. 4. method stability under small variations
  3. 6. EI calibrant example
  4. 8. ICH guideline for analytical validation
  5. 10. FT ion trap in magnetic field, extreme accuracy
  6. 11. precision precision under different conditions
  7. 13. electronegative atoms withdraw electron density in NMR
  8. 16. GC + MS hyphenation
  9. 17. measures only intended analyte
  10. 18. shift NMR signal position on delta scale (ppm)
  11. 20. early known compound ID by NMR
  12. 22. state NMR for solid compounds
  13. 23. HPLC component where separation occurs
  14. 24. spectrum HPLC-MS output showing molecular weight
  15. 26. modern NMR using pulsed radiation and FT
  16. 27. MS application for protein identification
  17. 30. DC + RF field ion separation
  18. 32. MS not routine in QC, mostly R&D
  19. 34. HPLC-MS interface using UV light for non-polar compounds
  20. 36. ratio γ in NMR energy equation
  21. 37. results proportional to concentration
Down
  1. 1. MS ionization using high voltage at atmospheric pressure
  2. 3. HPLC-MS part that converts liquid to gas ions
  3. 5. ions travel in tube; smaller ions arrive first
  4. 6. most common NMR nucleus
  5. 7. HPLC-MS interface for polar, high-MW compounds
  6. 9. documented proof that a method is fit for purpose
  7. 12. high-energy electron bombardment ionization
  8. 14. reduced electron density increases resonance frequency
  9. 15. NMR to distinguish enantiomers
  10. 17. NMR nuclei property behaving like tiny magnets
  11. 19. π-electron magnetic effect in NMR
  12. 21. old NMR sweeping RF frequency
  13. 22. surface ionization for forensics
  14. 25. closeness of measured value to true value
  15. 28. laser + matrix ionizes large biomolecules
  16. 29. quad triple quadrupole for precursor/product ions
  17. 31. corona discharge ionization for less polar drugs
  18. 33. MS/MS for structural info
  19. 35. interval between lowest and highest concentrations