Stem Cells 1

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Across
  1. 2. The rapidly dividing cell type in stem cell systems
  2. 4. Progenitor cells and hematopoietic stem cells are _____ because they can only form a few cell types
  3. 5. ______ is the best understood stem cell system, and refers to the formation of blood cells from stem cells in bone marrow
  4. 9. The process by which a non stem cell is differentiated into a different type of cell using varying transcription factors
  5. 11. Cell death caused by internal damage to DNA or external death signals that does not cause inflammation
  6. 13. Type of cancer that does not follow the stem cell model, does not show hierarchical structure
  7. 15. Special proteases responsible for apoptosis
  8. 16. Stem cells created using retroviruses transducing specific "Yamanka" genes, reverting it back to a pluripotent state.
  9. 17. Where you are likely to find intestinal stem cells
  10. 18. Embryonic stem cells are considered _______ and can form all 3 germ layers
  11. 20. Inhibiting this in colorectal cancer cells causes them to become normal villus cells
  12. 21. Tumor consisting of multiple germ layers, result of transplanting undifferentiated stem cells
Down
  1. 1. Stem cells are physiologically ______, meaning they haven't been differentiated
  2. 3. Telomerase is a _______ because it produces DNA from an RNA template
  3. 6. The germ layer that forms muscle and blood cells
  4. 7. Located at the very bottom of crypts and act as niche cells for ISC’s
  5. 8. A GPCR and signaling pathway that regulates ISC proliferation
  6. 10. Protective, noncoding repeats of DNA at the end of chromosomes that prevent damage to genes during replication, and shorten with age
  7. 12. One of the three types of progenitors in the Hematopoietic stem cell hierarchy
  8. 14. To determine if a cell is an HSC, you can perform a functional test or look for _____ on the cell surface
  9. 19. Stage of embryonic development that gives rise to the 3 germ layers