Stem Cells - Part 2

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Across
  1. 2. nuclear messenger that can pathologically accumulate with increased genetic damage to the cell
  2. 4. large tumor consisting of multiple germ layers, result of transplanting undifferentiated stem cells
  3. 6. cell capable of forming a new tumor
  4. 8. another gene transduced by retrovirus in iPS Cells
  5. 9. name of chromosome found in HSC derivaties of CML leukemia patients
  6. 14. If a transplant attacks the patients tissues and organ it is said to result in this type of disease
  7. 15. accumulation of these in a somatic cell lineage causes cancer
  8. 17. alternative source of stem cells that posses intermediate qualities between embryonic and adult stem cells
  9. 19. type of cancer that does not follow the stem cell model, does not show hierarchical structure
  10. 21. type of stem cell that can produce all cell and tissue types, ethically controversial
  11. 22. Routine but risky transplant used for several blood disorders
Down
  1. 1. high expression of this enzyme is responsible for limitless replicative potential of cancer cells
  2. 3. a controversial stem cell marker that correlates with tumorgenicity and stemness
  3. 4. process by which a non stem cell is differentiated into a different type of cell using varying transcription factors
  4. 5. another gene transduced by retrovirus in iPS Cells
  5. 7. one of the four iPS inducing genes that carries a risk of cancer
  6. 9. tumor supressor protein that, when mutated, causes cancer cells to evade apoptosis
  7. 10. type of stem cells that are rare and difficult to culture
  8. 11. stem cells created using retroviruses transducing specific "Yamanka" genes, reverting it back to a pluripotent state.
  9. 12. a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells
  10. 13. a laboratory technique for creating a clone embryo in which a somatic nucleus is fused with a denucleated egg cell
  11. 16. comples in the Wnt signaling pathway that is usually the first to mutate
  12. 18. process by which sperm fertilizes an egg outside the body
  13. 20. type of transporter highly expressed in both cancer stem cells and tissue stem cells
  14. 23. another gene transduced by retrovirus in iPS Cells