Strong as Bones

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Across
  1. 3. Red bone marrow is also called ______ tissue (produces red blood cells), while yellow bone marrow is similar to adipose tissue.
  2. 6. Osteogenic cells are stem cells, osteoblasts are the builders, osteocytes do maintenance, and osteoclasts breakdown and _____ bone.
  3. 7. _______ ossification is the embryonic development of flat bones.
  4. 9. Bone elongation is done at the ________ plate through hypertrophy (increase of cell number) and hyperplasia (increase in cell size) of the chrondrocytes.
  5. 11. Cartilage is present during _______ ossification.
  6. 14. _______ lowers blood calcium through hypercalcemia.
  7. 16. Long bones connect to cartilage, while flat bones are produced by _______.
  8. 18. The matrix is hardened by deposition of calcium ______ (calcification).
  9. 19. Acromegaly is a growing disorder that is caused by excess growth hormone secretion during adult years, while _______ is caused by excess growth hormone produced in juvenile years.
Down
  1. 1. Short limbs are attributed to a defect in the GPC6 gene, which localizes hyperplasia of the ________ zone and elongates long bones (no hyperplasia of the chondrocytes, epiphyseal plate does not divide to grow long).
  2. 2. The calcium homeostasis of bone is regulated by hypocalcemia (low calcium levels) and __________ (high calcium levels).
  3. 4. ______ is when bones are brittle from low bone mass.
  4. 5. _______, testosterone, and growth hormone lower blood calcium by building bone (hypercalcemia) with osteoblasts.
  5. 8. Bone as an organ includes groups of tissues (nervous, cartilage, blood, spongy, and compact bone) with a similar function, bone as a tissue includes groups of _____ with a similar function.
  6. 10. _________ hormone (PTH) also raises blood calcium through hypocalcemia.
  7. 12. Organic matter in the matrix is composed of collagen and other proteins and is produced by ______, while inorganic matter is composed of hydroxyapatite (strength).
  8. 13. Calcitriol is a form of ______ D, and boosts blood calcium through hypocalcemia.
  9. 15. Bone widening due to increased use is called deposition, while bone _______ is the thinning of bones do to disuse.
  10. 17. Wolff’s Law of Bone states that the more _____ on a bone, the more compact and spongy bone will grow to compensate.