Structure of bone and the roles of osteoblasts, osteoclasts, osteocytes in bone formation, resorption, and remodelling

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Across
  1. 4. Unmineralised organic matrix laid down before calcification
  2. 5. Restrains resorption by promoting osteoclast apoptosis; its fall drives post-menopausal bone loss
  3. 9. Spongy(cancellous) bone with high turnover, such as in vertebrae and epiphyses
  4. 12. Terminally differentiated osteoblast trapped in matrix, the chief mechanosensor
  5. 13. Tiny cavity housing a single osteocyte
  6. 16. Thyroid C-cell hormone that directly inhibits osteoclasts
  7. 17. Paradoxical hormone, where continuous exposure causes bone resorption, intermittent builds up bone
  8. 18. Haversian system; the structural unit of compact bone
  9. 19. Large multinucleated resorbing cell, from the monocyte lineage
Down
  1. 1. Type I fibre giving bone its tensile strength
  2. 2. Disorganised, rapidly laid bone of the foetus and fracture callus. This is later replaced by lamellar
  3. 3. Lifelong coupled cycle of resorption and formation, the balance results in bone mass
  4. 6. Calcium-phosphate crystal providing compressive strength
  5. 7. Bone-forming cell; secretes osteoid and triggers mineralisation
  6. 8. Concentric ring of matrix wrapped around a central canal
  7. 10. Dense compact bone forming the diaphyseal shell
  8. 11. Osteoblast-expressed ligand driving osteoclast maturation; decoy-blocked by OPG
  9. 14. Microscopic channels linking osteocytes for nutrient and signal transfer
  10. 15. Fibrous outer sheath; source of appositional growth