T Cell Development and MHC

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Across
  1. 3. In this kind of selection during the double positive stage of T cell development, if TCR binds to self MHC/Ag with low affinity, the T cell survives
  2. 6. MHC I is used to identify cells that are virally infected or ____________
  3. 8. The single positive stage of T cell development occurs in the ______ ________ (two words)
  4. 10. ___________ rearrangement of the heavy chain occurs during the transition of the double negative stage 1 to 2 of T cell development
  5. 11. MHC II molecules load ___________ peptides while MHC I molecules load self peptides
  6. 12. After T cells originate in the bone marrow they move into the _________ to mature
  7. 13. This transcription factor causes mTECs (medullary thymic epithelial cells) and DCs to express self-Ag not normally found in thymus
Down
  1. 1. The double negative stages and double positive stage of T cell development take place in the ______ _______ (two words)
  2. 2. MHC molecules are membrane-bound ________________ that carry peptides
  3. 3. Both CD4 and CD8 are ________ during the double positive stage of T cell development
  4. 4. These cells express Notch ligand that bind to the notch receptor on precursor cells and pushes them toward the T cell lineage
  5. 5. In this kind of selection during the double positive stage of T cell development, high binding to self MHC/Ag = removal via apoptosis and no binding to self MHC/Ag = death by neglect
  6. 7. CD4 and CD8 are ________during the double negative stages of T cell development
  7. 9. MHC I molecules are present on all __________ cells
  8. 13. Completion of ______ chain rearrangement occurs in the double positive stage of T cell development