TDDS

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Across
  1. 3. Delivery of charged compounds using an electrical field.
  2. 8. Chemical that reversibly alters stratum corneum to increase permeability
  3. 10. weight Ideal ≤400 for effective transdermal drug delivery.
  4. 11. Use of high-frequency ultrasound to enhance drug penetration.
  5. 14. diffusion Method by which drug molecules penetrate the keratinized tissue.
  6. 15. TDDS design embedding the drug directly in the adhesive.
Down
  1. 1. coefficient Factor influencing rate of transport between stratum corneum and vehicle.
  2. 2. TDDS design containing drug in a separate compartment.
  3. 4. Mechanism by which TDDS prevents sweat from passing and increases skin hydration.
  4. 5. Living tissue layer between stratum corneum and dermis.
  5. 6. Vascularized layer under the epidermis where drugs enter general circulation.
  6. 7. Increased by TDDS acting as an occlusive moisture barrier, favors absorption.
  7. 9. The medium carrying the drug in the TDDS.
  8. 12. corneum The 10–15 μm outer layer of nonliving skin tissue, major barrier to drug transport.
  9. 13. Component concentrated in extracellular phase that influences first step of absorption.