Test on Diabetes mellitus

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Across
  1. 7. Accumulation of this substance in tissue is responsible for long term complications in diabetes (like end organ damage)
  2. 8. This insulin can be given intravenously
  3. 9. The most potent insulinotropic sulfonyl urea, which has property of sequestered in beta cells
  4. 10. All insulin or insulin analogues preparations available at neutral pH, except this one, which is at pH 4
  5. 13. This ADR of insulin occurs due to local reaction on subcutaneous fat around injection site
  6. 14. Long term use of metformin can result in this adverse effect
  7. 16. This DPP4 inhibitor does not requires dose adjustment in renal failure patients, but it increases risk of heart failure
  8. 17. Insulin secretion will_______by cholinergic-muscarinic activation by Ach
  9. 18. Beta blockers can mask all the warning signs of hypoglycaemia, except this one
  10. 20. The most rapidly acting insulin analogue
Down
  1. 1. This organ receives the highest concentration of endogenous insulin but not the exogenous insulin
  2. 2. Secreted by beta cells of pancreas along with insulin that also helps in decreasing blood sugar
  3. 3. Insulin acts on this specific receptor located on cell membrane of every cells (practically)
  4. 4. The longest acting insulin, which can be mixed with other insulins too
  5. 5. The only drug approved for treatment of both type 1 DM as well as type 2 DM (other than insulin)
  6. 6. A hormone, which is a “universal inhibitor”, inhibits the release of insulin from beta cells
  7. 11. A long acting insulin, should never mix with other insulin
  8. 12. This injectable ADA used in type 2 DM and recently approved for management of obesity
  9. 15. Only oral ADA that has been demonstrated to reduce macrovascular events in type 2 DM
  10. 19. Long acting inhaled insulin preparation (approved by US FDA in 2014, withdrawn from market, by EMA in 2018)