The Complement System 2025-26

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Across
  1. 4. C3b binds pathogen surface and makes pathogen more readily recognized by phagocytes and it is called as ....
  2. 5. this substance produced by over activation of kallikrein pathway results in mucosal and submucosal edema
  3. 10. This anchoring protein present in the cellmembrane anchors the binding of DAF and CD59 molecules
  4. 12. This complement pathway is initiated with the binding C1qrs complex to the antibody attached to the pathogen surface
  5. 15. Majority of the complement proteins are synthesized here
  6. 16. C5a also serves as ....... for neutrophils
  7. 17. C4b2a is ....... of classical pathway
  8. 18. lectin molecules bind to these sugar moieties present on microbial surfaces and activate MBL pathway
  9. 20. Complement proteins are synthesized in the form of inactive enzymes also known as ...
Down
  1. 1. Membrane attack complex is important for killing of Gram-negative bacteria such as .....
  2. 2. C3a and C5a complement proteins induce inflammation by activating mast cells and others. They can also lead to shock like state if more activated. Hence they are called as .....
  3. 3. Deficiency of C-esterase inhibitor results in a disease which is characterized swelling of lips, face, pharynx, and other mucosal areas
  4. 6. This factor stabilizes C3 convertase of alternative pathway on the microbial surface
  5. 7. Ineffective elimination of immune complexes may result in deposition of these immune complexes on tissues and result in autoimmune disease called as .....
  6. 8. The complex C5b-9 is also referred to as ....
  7. 9. This complement pathway does not require antibody for its activation
  8. 11. This molecule prevents C9 binding and formation of membrane attack complex on the red cell membrane
  9. 13. C9 complement functions exactly like this toxic molecule produced by NK cell and Cytotoxic T cell
  10. 14. This molecule embeded in red cell membrane prevents formation of C3 convertase on the cell membrane
  11. 19. This clinical condition characterized by hematuria and hemoglbulinuria is due to lack of Decay accelerating factors in the cell membrane of erythrocytes