The Great Hypertension Trials Crossword

12345678910111213141516
Across
  1. 2. There was a significant 25% reduction in the rate of fatal or nonfatal stroke in hypertensive patients with LVH randomized to losartan instead of atenolol.
  2. 4. Lower BP associated with lower total kidney volume in PKD
  3. 6. Ramipril significantly reduces the rates of death, myocardial infarction, & stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or heart failure.
  4. 7. ACE inhibitor/calcium channel blocker better than beta blocker/thiazide diuretic combination in reducing major cardiovascular outcomes in people with hypertension.
  5. 10. Losartan has a renoprotective effect in diabetic nephropathy
  6. 12. No significant reduction of SBP in resistant hypertension 6 months after renal-artery denervation as compared with a sham control.
  7. 14. Ramipril and Telmisartan in combination associated with increased risk of AKI
  8. 15. Tight blood pressure control in patients with hypertension & type 2 diabetes achieves a clinically important reduction in the risk of deaths related to diabetes, complications related to diabetes, progression of diabetic retinopathy & deterioration in visual acuity.
  9. 16. Reduction in all-cause and cardiovascular mortality with more intensive BP target (SBP less than 120mmHg)
Down
  1. 1. Compared with doxazosin, chlorthalidone yields essentially equal risk of CHD death/nonfatal MI but significantly reduces the risk of combined CVD events, particularly CHF, in high-risk hypertensive patients.
  2. 3. AOBP is more accurate than office BP
  3. 5. Perindopril and indapamide reduce BP 12/5 & significantly reduce rate of stroke in normal and hypertensive patients with previous stroke/TIA.
  4. 7. No additional benefit of slowing progression of hypertensive nephrosclerosis was observed in African-Americans with the lower BP goal, but still some additional reduction in proteinuria.
  5. 8. Candesartan 16 mg once daily is as effective as lisinopril 20 mg once daily in reducing blood pressure and microalbuminuria in hypertensive pts with type 2 diabetes.
  6. 9. No benefit in diabetic kidney disease for combined ACE inhibitor and ARB
  7. 11. Among elderly patients with isolated systolic hypertension, antihypertensive drug treatment starting with nitrendipine reduces the rate of cardiovascular complications.
  8. 13. Treatment of the patients older than 80 years remains beneficial with diuretic with or without ACE inhibitor.