The Superbug Challenge

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Across
  1. 4. Broad-spectrum beta-lactam class often reserved for severe infections caused by multidrug-resistant Gram-negative bacteria
  2. 5. Molecule replacing terminal alanine in vancomycin-resistant enterococci, reducing drug binding
  3. 8. Mobile genetic element capable of capturing and expressing resistance gene cassettes
  4. 9. Methicillin-resistant Staphylococcus aureus causing skin, bloodstream, and device-associated infections
  5. 11. Altered penicillin-binding protein responsible for methicillin resistance in Staphylococcus aureus
  6. 12. Metallo-beta-lactamase first described from the Indian subcontinent and now disseminated globally
  7. 13. Lowest concentration of an antimicrobial agent that inhibits visible bacterial growth
  8. 16. Genus containing the most common bacterial cause of community-acquired urinary tract infections
  9. 17. Important nosocomial pathogen frequently associated with ESBL production and carbapenem resistance
  10. 18. Vancomycin-resistant enterococci frequently implicated in healthcare-associated infections
  11. 19. Direct transfer of plasmids between bacteria through cell-to-cell contact
  12. 20. Resistance mechanism demonstrated by synergy between third-generation cephalosporins and clavulanic acid
  13. 22. Plasmid-mediated determinant responsible for transferable resistance to colistin
  14. 23. Coordinated interventions designed to improve and measure appropriate antimicrobial use
Down
  1. 1. Describes antimicrobial activity that inhibits bacterial multiplication without killing the organisms
  2. 2. Phenotypic method used to detect inducible clindamycin resistance in staphylococci
  3. 3. Resistance mechanism involving active extrusion of antibiotics from bacterial cells
  4. 4. Group of Enterobacterales exhibiting resistance to carbapenem antibiotics
  5. 6. Bacteriophage-mediated transfer of bacterial genetic material
  6. 7. Cumulative report summarizing antimicrobial susceptibility patterns within a healthcare setting
  7. 10. WHO AWaRe category intended for antibiotics that should be preserved as last-resort agents
  8. 14. Phenomenon in which a bacterial population contains a resistant subpopulation despite overall susceptibility
  9. 15. Horizontal gene transfer involving uptake of naked DNA from the environment
  10. 16. Group of multidrug-resistant pathogens notorious for causing healthcare-associated infections
  11. 21. Stewardship strategy involving narrowing antimicrobial therapy based on culture results