The Superbug Challenge

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Across
  1. 2. Transfer of bacterial genes mediated by bacteriophages
  2. 4. Tuberculosis resistant to at least isoniazid and rifampicin
  3. 6. Enzyme that hydrolyses third-generation cephalosporins and is inhibited by clavulanic acid
  4. 8. A common upper respiratory tract infection that highlights the problem of irrational antibiotic prescribing
  5. 10. Multidrug-resistant staphylococcal pathogen identified in the laboratory using cefoxitin disc testing
  6. 13. Bacterial resistance mechanism involving active pumping out of antibiotics from the cell
  7. 15. Stewardship practice of changing to a narrower-spectrum antibiotic after culture results become available
  8. 16. Term used for antibiotics that inhibit bacterial growth without killing bacteria
  9. 21. Collaborative approach involving human, animal, and environmental sectors to address antimicrobial resistance
  10. 22. Disc diffusion method commonly used for routine antimicrobial susceptibility testing
  11. 24. Coordinated interventions aimed at improving and measuring appropriate antimicrobial use
Down
  1. 1. Lowest concentration of an antimicrobial agent that inhibits visible bacterial growth
  2. 3. Phenotypic method used to detect inducible clindamycin resistance in staphylococci
  3. 5. WHO AWaRe category containing antibiotics that should be preserved for selected indications
  4. 7. Term used for antibiotics that kill bacteria
  5. 8. Transfer of resistance genes through direct cell-to-cell contact using a pilus
  6. 9. Hospital summary report showing susceptibility patterns of bacterial isolates
  7. 11. Altered penicillin-binding protein responsible for methicillin resistance in Staphylococcus aureus
  8. 12. Important laboratory investigation that should ideally be performed before initiating antibiotic therapy
  9. 14. First-line antitubercular drug whose resistance is detected by CBNAAT and serves as a surrogate marker for MDR-TB
  10. 17. Uptake of naked DNA from the environment by competent bacteria
  11. 18. Antibiotic used as a surrogate marker for the detection of methicillin resistance in Staphylococcus aureus
  12. 19. Popular media term used to describe multidrug-resistant microorganisms
  13. 20. Abbreviation for enterococci that have acquired resistance to vancomycin
  14. 23. Group of six major multidrug-resistant pathogens responsible for many healthcare-associated infections