Tolerance Crossword Puzzle

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Across
  1. 4. Failure of tolerance leads to disease
  2. 7. Mechanism by which unresponsive lymphocytes survive
  3. 9. Cell type that induces T cell anergy
  4. 10. Gene crucial for Treg development
  5. 12. Site of peripheral tolerance induction
  6. 13. Pathogens that cause damage at both extremes of immune response
  7. 16. Pathogens that cause damage only with weak immune responses
  8. 18. Framework that defines host–microbe damage balance
  9. 19. Cytokine produced by regulatory T cells
  10. 20. Process by which Tregs suppress effector T cells
Down
  1. 1. Process that allows self-reactive B cells to change specificity
  2. 2. Site of central tolerance induction
  3. 3. Abbreviation for thymus-derived regulatory T cells
  4. 5. Pathogens that cause damage enhanced by strong immunity
  5. 6. Pathogens that only cause damage with strong immune responses
  6. 8. Immune state that avoids reaction to self
  7. 11. Abbreviation for peripherally-induced regulatory T cells
  8. 14. Process that deletes self-reactive lymphocytes
  9. 15. Metabolic process that prevents T cell tolerance
  10. 17. Pathogens that cause damage with both weak and normal immune responses