Topic 11: Cell Interactions

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Across
  1. 3. This is the most abundant protein in the human body and a major component of the skin and bone.
  2. 6. This cell adhesion protein help cells to adhere to the ECM.
  3. 8. Selectins are involve in initiation _____________ involving migration of leukocytes along the vascular endothelium
  4. 10. Are glycoproteins that link the cell adhesion molecules (eg. integrin) to component of the ECM (eg. collagen), allowing for cellular function such as cell migration, differentiation and wound healing.
  5. 11. If a cell wanted to adhere to the ECM using actin filament what type of cell junction should it use?
  6. 13. Which type of CAM is best known for presenting foreign particles to immune cells?
  7. 14. Multicellular organism cannot exist without cell________
  8. 17. _________ is an ECM component that is secreted by fibroblasts to provide elasticity to lung, skin, bladder and cartilage tissues.
  9. 18. ECM of the heart tissues include the hyaluronan, proteoglycan, collagen, fibronectin and ________ factors important for cardiomyocytes development and function.
  10. 19. What cell type are tight junctions commonly found in, preventing movement between these cells?
Down
  1. 1. This is an adhesive protein and a component of the ECM.
  2. 2. This is found in the basement membrane and forms a heterotrimer that polymerises via interaction at their LN domains of the chain
  3. 4. This cell adhesion protein play an important role during fetal development, separating different tissue layers, cellular recognition and cellular migration.
  4. 5. Specific tumour-cell ________help in tumour progression by targeting endothelial or by altering the structure and composition of ECM.
  5. 7. _________proteins in ECM such as collagen and elastin provide tensile strength to the tissue.
  6. 9. A supplement in cell culture medium for cell growth and adherence.
  7. 12. This transmembrane protein comprised of CRP repeats and a lectin-like domain
  8. 15. Proteoglycans have a net ______charge which binds Na+ and therefore attracts and retain water within the ECM.
  9. 16. Arthritis is due to activated ________ that produce matrix metalloproteinases that degrades ECM in the joints.
  10. 20. ECM are produced intracellularly by resident cells and are secreted via __________