Transdermal Drug Delivery System

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Across
  1. 4. PATCHES are designed to support the passage of drug substances from the surface of the skin through its various layers and into the systemic circulation.
  2. 5. first transdermal system for hypertension,- Transdermal Clonidine
  3. 6. also known as high-frequency ultrasound, is a physical menthod of delivery that enhance transdermal drug delivery by influencing the integrity of the stratum corneum, affecting its penetrability.
  4. 8. systems these are systems that incorporate a drug matrix layer between the backing and the frontal layers.
  5. 10. reservoir or matrix system to store and release the drug at the skin site
  6. 11. occlusive backing it is TDDS layer that protects the system from environmental entry and from loss of drug from the system
  7. 13. pass effect
  8. 15. It is a route where polar drugs favor transport between cells
Down
  1. 1. is an advantage of TDDS where the initial pass of a drug substance is through the systemic and portal circulation avoiding the deactivation by digestive and liver enzymes.
  2. 2. It is the route where nonpolar drugs tend to cross the cell barrier through the lipid-rich regions
  3. 3. is a enhancer that increases skin permeability by reversibly damaging or altering the physicochemical nature of the stratum corneum to reduce its diffusional resistance
  4. 7. adhesive layer to maintain contact with the skin after application.
  5. 9. is a physical method of delivery of a charged chemical compound across the skin membrane using an electrical field.
  6. 12. controlled transdermal is a system designed to contain a drug reservoir, or pouch, usually in liquid or gel form; a rate-controlling membrane; and backing, adhesive, and protecting layers
  7. 14. ___ drugs are suitable candidates for transdermal delivery