Translational at Loon Lake 2026

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Across
  1. 4. Animal models genetically engineered or engrafted with human genes or immune systems
  2. 8. Biological experiments or modelling conducted on a computer rather than in a lab or living organism
  3. 9. Time required for the body to reduce a drug's plasma concentration by half
  4. 10. A measurable endpoint used in studies as a substitute for a direct clinical outcome
  5. 11. Tissue or cell graft transplanted from one species into another, frequently used in oncology models
Down
  1. 1. The final phase of ADME, responsible for removing parent drug and metabolites from the body
  2. 2. Lab technique (like ELISA) utilizing antibodies to detect and quantify protein biomarkers
  3. 3. The fluid-filled space surrounding cells within a tissue that a molecule must penetrate to reach its target
  4. 5. Safety ____: The ratio calculated between the toxic dose in animals and the therapeutic dose in humans
  5. 6. Executing quantitative models in silico to forecast virtual trial outcomes and biological responses
  6. 7. Short for testing that assesses whether a substance causes damage to DNA