TTS Metabolisme Xenobiotik Kelompok 3

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Across
  1. 4. The process of causing DNA changes that can lead to cell dysfunction or cancer.
  2. 7. Ongoing monitoring for drug side effects and safety problems in real-world use.
  3. 9. An enzyme that adds oxygen to a chemical to make it easier to process or remove.
  4. 10. An unhealthy shift in gut microbes that can change how toxins and drugs are handled.
  5. 12. Recycling of chemicals between the liver and the intestine, which can prolong drug effects.
  6. 13. A Phase I reaction that removes an alkyl part of a molecule, changing its activity and clearance.
  7. 14. A chemical that becomes cancer-causing only after the body activates it.
Down
  1. 1. A reaction that uses water to split a chemical into smaller, often more removable parts.
  2. 2. Using gene-expression and omics data to understand how toxins affect the body.
  3. 3. A family of proteins that helps the body break down many drugs and chemicals.
  4. 5. A Phase I reaction that can create a highly reactive epoxide that may be harmful to cells.
  5. 6. Very tiny particles that can enter tissues easily and may have unique toxicity risks.
  6. 8. A Phase I reaction that adds a hydroxyl group, often making a chemical less fat-soluble.
  7. 11. A natural waste pigment that can build up if detox pathways are impaired.