Vasopressors and Inotropes

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Across
  1. 2. Rapid loss of response to a drug such as ephedrine after repeated doses
  2. 7. Oral alpha agonist for orthostatic hypotension; lasts 2–3 hours
  3. 9. Refers to the strength of myocardial contraction
  4. 10. Indirect sympathomimetic that releases norepinephrine; subject to tachyphylaxis
  5. 11. Enzyme inhibited by milrinone and amrinone to increase cAMP
  6. 13. Balanced catecholamine and mast cell stabilizer; first choice for anaphylaxis
  7. 14. Drug that stimulates alpha-adrenergic receptors causing vasoconstriction
  8. 20. Chemical messenger released by neurons to transmit signals across synapses
  9. 22. Condition treated with hydroxocobalamin via nitric oxide scavenging
  10. 24. Non-sympathomimetic vasopressor; “new vasopressin” with potent vasoconstriction
  11. 25. Calcium sensitizer that stabilizes troponin-Ca2+ binding without increasing Ca2+ affinity
  12. 26. Class of endogenous compounds including dopamine, norepi, and epi
  13. 27. Vascular region dilated by low-dose dopamine
Down
  1. 1. Narrowing of blood vessels; increases systemic vascular resistance
  2. 3. Oral calcium sensitizer used to treat congestive heart failure
  3. 4. PDE3 inhibitor that increases cAMP and Ca2+ to improve inotropy; hepatic excretion
  4. 5. Blocks guanylate cyclase to reverse refractory vasodilation; rescue agent for MAP<50
  5. 6. Non-sympathomimetic vasopressor acting via V1, V2, and V3 receptors
  6. 8. Endogenous catecholamine with potent alpha effects and little change in cardiac output
  7. 12. Direct alpha agonist similar to phenylephrine but longer acting
  8. 15. Older PDE3 inhibitor that increases contractility by increasing cAMP
  9. 16. Synthetic catecholamine with B1>B2 (3:1) activity; increases myocardial oxygen consumption
  10. 17. Precursor catecholamine that activates D1/D2 receptors at low doses; indirect acting “dumb drug”
  11. 18. Direct alpha agonist with rapid onset and short duration
  12. 19. Drug that stimulates beta-adrenergic receptors to increase heart rate and contractility
  13. 21. Also known as Cyanokit; nitric oxide scavenger and cyanide antidote
  14. 23. Potent nonselective beta agonist (B1=B2); no alpha effect causing vasodilation