Viral Oncogenesis 2024

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Across
  1. 3. Genes that mediate cellular signal transduction pathways that promote cell growth, proliferation, and differentiation.
  2. 7. Gamma herpesvirus causative agent of Burkitt’s lymphoma,Hodgkin’s Disease, and Nasopharyngeal carcinoma.
  3. 9. Tumor suppressor protein that senses DNA damage, unscheduled DNA synthesis, and promotes apoptosis.
  4. 10. Viral proteins expressed in transformed cells.
  5. 12. Step that can trigger oncogenesis.
  6. 14. A series of steps that allows a cell to grow and divide.
  7. 15. Host oncogenes acquired by retroviruses that can lead to transformation and oncogenesis once mutated.
  8. 16. Avian Rous Sarcoma Virus characterized by rapid tumor formation.
Down
  1. 1. Causative agent of adult T cell leukemia.
  2. 2. Insertion of viral promoter (LTR) activates the expression of endogenous oncogenes
  3. 4. Causative agent of Kaposi Sarcoma.
  4. 5. Process that allows P53 tumor suppressor protein to be degraded.
  5. 6. Cells that can undergo viral transformation in vitro characterized by expression of viral T antigens and integration of viral genomes.
  6. 8. Tumor suppressor protein that is responsible to control transition from G1 to S in the cell cycle.
  7. 11. Causative agent of cervical cancer.
  8. 13. Requires the accumulation of mutations in oncogenes and in tumor suppressor genes