What's my Job? (Immune Cell Edition)

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Across
  1. 3. engulf and process cell debris, pathogens, and cancer cells. They are involved in wound healing, tissue regeneration, and pro-inflammatory activities.
  2. 6. mediate humoral (soluble) immunity through the production of antibodies
  3. 7. represent the first line of defence in response to invading microbes, by phagocytosis of pathogens and/or release of antimicrobial factors contained in specialised granules
  4. 9. extremely modified protein components, also identified as antibodies, match foreign antigens, like a key and lock.
  5. 12. cells that continue to circulate in the bloodstream even after infection to prevent or reduce the response time to subsequent infections.
  6. 13. cells which kill infected/malignant host cells, like cells that have been infected by an intracellular microbe. They are regulated by regulatory T-cells to switch them 'off' and prevent their activation.
  7. 14. is ogenitor derived from the common lymphoid progenitor cells and leaves the bone marrow through the bloodstream to enter the thymus gland
  8. 15. present in tissues like skin, lungs, and intestines. They present antigens to B and T cells and also secrete cytokines
Down
  1. 1. produced from the bone marrow and are found in the bloodstream and tissues in reasonably low quantities. They are cytotoxic cells that have small granules with perforins and granzymes and destroys infected cells and cancer cells rapidly.
  2. 2. granulocytes that secrete heparin, histamine, and other factors. They help in wound healing, angiogenesis, and elimination of parasites.
  3. 4. interacts with other immune cells to orchestrate an effective immune response
  4. 5. the largest granulocytic leukocytes with a bilobed nucleus. They have histamine-rich granules and are involved in inflammatory responses. They help in the secretion of cytokines involved in the maturation of T-helper cells.
  5. 8. effector cells in the immune system. They have a beneficial role in host defence against nematodes and other parasitic infections and are active participants in many immune responses. Now,they mostly play a role in allergic reactions.
  6. 10. these lymphocytes emerge and divide into plasma cells, which in effect develop into immunoglobulins (antibodies). Differentiates into Memory cells & Plasma cells.
  7. 11. A type of phagocytic cell located in the bloodstream that, when moving to tissues, transforms into a macrophage.