‘Year in’ type 2 diabetes: epidemiology, aetiology and treatment

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Across
  1. 3. The _____ Investigators examined the relationship between the DPP-IV inhibitors/GLP-1 receptor agonists and heart failure.
  2. 5. In the DEVOTE study, degludec was _________ to glargine in regard to severe hypoglycaemia in type 2 diabetic patients with high cardiovascular risk.
  3. 8. The _________ study demonstrates that empagliflozin reduces the risk of non-fatal myocardial infarction and cardiovascular death and slows the progression of diabetic kidney disease.
  4. 9. The ______trial reported that bariatric surgery plus intensive medical therapy was superior to the latter alone in improving glycaemic control, cardiovascular risk factors and quality of life after 5 years in moderate- and severely-obese patients with type 2 diabetes.
  5. 10. ______ examined the long-term effect of an intensified, multifactorial intervention on gained years of life.
  6. 11. Transplantation of cold-adapted ____ increases beige adipocytes in mice.
Down
  1. 1. In more affluent countries, recent studies demonstrate a ____ in all-cause mortality and the incidence of cardiovascular complications in patients with type 2 diabetes.
  2. 2. In the ________ study, liraglutide lowered cardiovascular death and non-fatal events in patients with type 2 diabetes.
  3. 4. _______ reported a cardiovascular benefit for canagliflozin.
  4. 6. Reduced _______ adipose tissue storage capacity is a key determinant of insulin-resistance and that this link is mediated by specific and multiple genetic factors.
  5. 7. In the Devote study, degludec was non-inferior to ______ in relation to cardiovascular events.
  6. 10. In _______, semaglutide lowered cardiovascular death and non-fatal events in patients with type 2 diabetes.