Across
- 2. Transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 3. The end stage of disease in HIV infection
- 7. A mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 8. Soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin
- 9. Short DNA sequences flanking Ig and TCR V, D and J gene segments that serve as the binding sites for the RAG complex
- 11. Large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells
- 13. Transcription factor expressed in Treg cells that is needed for Treg cell function
- 15. Immunoglobulin secreted by plasma cells
- 17. Upon activation differentiate into cytotoxic T lymphocytes
- 18. Highly active anti-retroviral therapy: multiple drug treatment for HIV infection
- 21. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 22. Designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
- 23. Repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 26. Subset of CD4+ T cells characterized by the cytokines they produce
- 27. Family name for cytokines that help cells to resist viral infections
- 28. The regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
Down
- 1. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
- 4. Cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
- 5. Amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 6. SIg on B cells that binds Ag and transmits signal 1 to activate B cells
- 10. Autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
- 12. Upon activation differentiate into distinct Thelper phenotypes with different roles in adaptive immunity
- 14. Receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 16. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
- 19. A cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 20. A cytokine produced by macrophages and T cells that is highly pro-inflammatory
- 21. Acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger Complement activation and acts as an opsonin
- 23. White blood cells with multi-lobed nuclei and cytoplasmic granules
- 24. End product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 25. Human immunodeficiency virus
- 26. T cell subset that is responsible for suppressing or limiting immune responses