Immunology acronym puzzle

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Across
  1. 1. white blood cells with multi-lobed nuclei and cytoplasmic granules
  2. 3. lymphocyte made by the thymus with two subsets
  3. 5. group of molecules on the cell surface that present peptide antigens to t cells
  4. 6. acute phase protein that binds to phosphocholine on certain bacteria, triggering complement activation and acts as an opsonin
  5. 7. a large mononuclear phagocyte in tissues and organs all over the body that contributes to both the innate and adaptive immune responses
  6. 10. CD8+ t cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
  7. 12. the antigen receptor on t cells
  8. 14. classification of cytokines that help cells resist viral infections
  9. 17. molecule that is recognized by antibodies/B cell receptors or a peptide that is presented by major histocompatibility complex molecules to T cell receptors
  10. 18. the part of an antibody responsible for antigen binding
  11. 21. Tcells that express a particular co-receptor protein which when activated will differentiate into cytotoxic T lymphocytes
  12. 22. a cell that presents major histocompatibility complex antigens to t cells
  13. 23. immunoglobulin secreted by plasma cells
  14. 24. the regions of the antigen binding loops of immunoglobulin molecules, antibodies and t cell receptors that come into contact with the antigen
  15. 25. name of major histocompatibility complex gene complex and proteins in humans
Down
  1. 1. repeating molecular patterns on microbes that are recognized by pattern recognition receptors on immune cells
  2. 2. large, granular lymphocyte that induces apoptosis of target cells that are virally infected or tumorous
  3. 3. a family of PRRs present on many leukocytes and epithelial cells that recognize PAMPs and help initiate immune responses
  4. 4. a b lymphocyte made by bone marrow that will secrete antibody molecules/b memory cells after differentiating into a plasma cell
  5. 8. adaptive immune response where t cells play major role
  6. 9. receptors on immune and epithelial cells that recognize and bind to pathogen associated molecular patterns on microbes
  7. 11. alpha, a pro-inflammatory cytokine produced by macrophages and t cells
  8. 13. Tcells that express a particular co-receptor protein which when activated will differentiate into T helper phenotypes with different roles in adaptive immunity
  9. 14. protein family of antibodies and b cell receptors
  10. 15. transcription factor that induces expression of many pro-inflammatory genes
  11. 16. end product of the complement cascade that creates an opening in the membrane of the pathogen to cause cell lysis
  12. 17. a cell that presents antigens to t cells
  13. 19. surface immunoglobulin that binds to antigens to activate B cell response
  14. 20. classification of cytokines, or chemical messengers that help immune cells communicate with other cells