2023 OCAT #2 Prep - LEC 10/11 - Gasotransmission, Drug Development

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Across
  1. 2. Prostanoid decreasing platelet aggregation
  2. 4. Precursor to prostanoids, keep away from kids' lunchboxes to avoid an angry note from their 2nd grade teacher
  3. 7. Constitutively expressed NO-producing enzyme in neurons, activated by Ca+ influx
  4. 9. Levorotary / left-handed NOS inhibitor - the only one that can be tested (acronym)
  5. 11. "Work to rule" in terms of following the doctor's orders
  6. 13. Backwards method of regulating neurotransmitter release
  7. 17. Section of druggable genome dominated by GPCR's
  8. 18. Type of cyclase activated by gasotransmitter binding to heme group
  9. 19. Going above and beyond to proactively follow a prescription
Down
  1. 1. No more need for fake eyelashes after taking this drug affecting intraoccular pressure
  2. 3. non-selective endocannabinoid
  3. 5. Proteinogenic amino acid precursor to NO
  4. 6. CB-1 selective endocannabinoid
  5. 8. Manipulate dose against population
  6. 10. Notion of Chari giving above a 50% on a NOCAT, or a drug with long duration of effect
  7. 11. Non-proteinogenic amino acid byproduct of NO production
  8. 12. Free-radical catalyzed (cis) product of AA's
  9. 14. Manipulate dose against single patient
  10. 15. Window between two -50's favourable to dose a drug
  11. 16. Bench to animal testing to double-blind controlled studies to post-marketing surveillance