Chapter 21 Crossword Review

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Across
  1. 8. The carbon that is one carbon away from the carbonyl group
  2. 10. Aldol addition and Claisen condensations both produce _,_-__ compounds.
  3. 12. The product of an aldol condensation is an_,-_ ___ aldehyde or ketone.
  4. 14. The resonance-stabilized intermediate that is a result of the alpha position of a ketone being deprotonated by a strong __ is an enolate
  5. 15. __ nucleophiles undergo 1,2-addition whereas less reactive nucleophiles prefer conjugate addition.
  6. 17. When an unsymmetrical ketone is used, bromination occurs at the more __ position
Down
  1. 1. If an enolate attacks an aldehyde, an __ addition reaction occurs.
  2. 2. Gilman reagents attack the beta position, which is 1,4-addition aka __ addition.
  3. 3. In aldehydes and ketones, only the __ protons are acidic
  4. 4. Ketones and aldehydes will undergo __ at the alpha position in acid-catalyzed conditions
  5. 5. Esters can undergo reversible condensation reactions called __ condensations.
  6. 6. Enolates are __ reactive than enols
  7. 7. The product has both aldehyde and __ groups.
  8. 9. The difference between the mechanisms of the acid- and base-catalyzed tautomerization mechanisms is the __ step
  9. 11. Grignard reagents tend to attack the carbonyl position. This is __, __ addition.
  10. 13. An __ ion is used as the base in a Claisen condensation.
  11. 16. The alpha position of a ketone or aldehyde can be alkylated in 2 steps: 1) formation of an __ and 2) treatment of the enolate with an alkyl halide.