Acne and appendageal disorder

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Across
  1. 3. Biologic therapy approved by the FDA in 2025 for moderate to severe hidradenitis suppurativa.
  2. 5. Rare benign sweat gland tumor with eccrine or apocrine origin.
  3. 7. First-in-class topical therapy targeting hormonal influence in acne pathogenesis
  4. 8. A novel mutation in which gene has been linked to a combined phenotype of Dowling-Degos disease and hidradenitis suppurativa, suggesting a pivotal role in Notch signaling within follicular structures​
  5. 11. Common topical agent exacerbating acne.
  6. 12. Acne variant with systemic symptoms and ulcerations.
Down
  1. 1. Neurotransmitter stimulating eccrine sweat glands.
  2. 2. Prickly heat rash caused by sweat duct obstruction.
  3. 4. AMP family contributing to innate immunity and dysregulated in acne
  4. 6. Malodorous sweat disorder linked to bacterial metabolism.
  5. 9. Primary site of Fox-Fordyce disease involvement.
  6. 10. Key inflammatory mediator driving HS progression.