TDDS

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Across
  1. 3. Increased by TDDS acting as an occlusive moisture barrier, favors absorption.
  2. 4. Method by which drug molecules penetrate the keratinized tissue.
  3. 8. Ideal ≤400 for effective transdermal drug delivery.
  4. 9. TDDS design containing drug in a separate compartment.
  5. 11. Delivery of charged compounds using an electrical field.
  6. 12. TDDS design embedding the drug directly in the adhesive.
  7. 13. Use of high-frequency ultrasound to enhance drug penetration.
  8. 14. The medium carrying the drug in the TDDS.
  9. 15. Mechanism by which TDDS prevents sweat from passing and increases skin hydration.
Down
  1. 1. The 10–15 μm outer layer of nonliving skin tissue, major barrier to drug transport.
  2. 2. Component concentrated in extracellular phase that influences first step of absorption.
  3. 5. Living tissue layer between stratum corneum and dermis.
  4. 6. Factor influencing rate of transport between stratum corneum and vehicle.
  5. 7. Vascularized ayer under the epidermis where drugs enter general circulation.
  6. 10. Chemical that reversibly alters stratum corneum to increase permeability