D1.3 Mutations and Gene Editing - Molly Dunn

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Across
  1. 3. cells that give rise to eggs or sperm
  2. 6. do not significantly affect the organism. typically occur in non-coding regions of the genome. often passed through generations without any significant effect
  3. 8. synthetic RNA molecule used in the CRISPR-Cas9 gene editing system. target specific genes for modification or deletion.
  4. 10. when insertions or deletions of nucleotides disrupt the reading frame of a genetic sequence.
  5. 12. technique where specific gene is intentionally made inoperative (removed or changed) to study its function
  6. 13. neutral mutations, do not change the amino acid sequence due to the degeneracy of the genetic code
Down
  1. 1. remain identical or similar across a species or group.
  2. 2. chemicals that cause mutation (mustard gas, nitrous acid, etc)
  3. 4. agents that can cause mutations (chemical or radiation)
  4. 5. rare but provide advantages to organism, increase fitness in a particular environment. lead to evolution of new traits or species.
  5. 7. region of DNA found in bacteria containing short, repeated sequences, and unique spacer sequences that are incorporated from foreign DNA encountered by the bacteria.
  6. 8. replacement of a single nucleotide with another, producing a variation. often found in the non-coding regions of DNA
  7. 9. endonuclease enzyme that can be used to cut DNA at specific target sites on a chromosome.
  8. 11. negative consequences on organism; causing, disease, developmental abnormalities, or reduce fitness/survival.