VASCULAR DISORDERS AND DISORDERS OF SECONDARY HEMOSTASIS

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Across
  1. 1. In 1993, a new and very common inherited thrombophilic syndrome was described
  2. 5. QUALITATIVE VWD
  3. 6. B Caused by the deficiency in factor IX
  4. 10. Capable of inactivating factor V LAIDEN
  5. 14. Discovered in 1944 by Professor Owren.
  6. 15. The disorder is uncommon in the general population.
  7. 19. Most frequently inherited disorder
  8. 20. Purified prothrombin complex
  9. 22. Discovered in Wisconsin
  10. 23. QUANTITATIVE VWD
  11. 24. Mutation results in the substitution of arginine (R) with
  12. 26. A.K.A Factor XIII
Down
  1. 2. A.K.A Labile Factor Deficiency
  2. 3. is found in patients receiving coumadin drugs and also in patients with liver disease
  3. 4. TCT means
  4. 7. Patients who are homozygous for factor X deficiency have
  5. 8. Demonstrated that the vWF portion of the VIII complex is reduced or absent in this disease.
  6. 9. GENE MUTATION VWD
  7. 11. Replacement therapy for hemophilia
  8. 12. is used to asses levels of vitamin K dependent factors in the new born.
  9. 13. Is seen due to decreased synthesis of plasminogen, decreased levels of plasmin inhibitors and impaired clearance from the circulation of plasminogen activators and fibrin split products.
  10. 16. Described this disorder as autosomal dominant disorder that produces a prolonged bleeding time and evidence of vascular fragility.
  11. 17. FFP means
  12. 18. there is a decreased level of plasma contact factors secondary to hepatic immaturity
  13. 21. Has CRM+ and CRMR variants of antigenic activity
  14. 25. Factor VII is synthesized in the