Enzyme crossword

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Across
  1. 2. reaction that absorbs free energy from the surroundings
  2. 5. sum of all chemical reactions occurring in a cell
  3. 8. the minimum energy required to start a chemical reaction
  4. 10. a model describing a flexible active site that changes shape to the substrate
  5. 11. breaking down large molecules into smaller ones
  6. 12. a model describing the active site having a set shape
Down
  1. 1. making large molecules from smaller ones
  2. 3. reaction that has a net release of free energy
  3. 4. substrates in a catalysed reaction
  4. 6. organic cofactors
  5. 7. substances released after the enzyme reaction
  6. 9. molecules that reduces or stop the enzyme from functioning