Across
- 2. — Loop diuretic that inhibits the Na+/K+/2Cl- cotransporter in the thick ascending limb of Henle.
- 6. — Converts plasminogen to plasmin, promoting fibrin-clot breakdown.
- 7. — Inhibits mycolic-acid synthesis in the mycobacterial cell wall.
- 10. — Beta-lactam that inhibits bacterial cell-wall synthesis by binding penicillin-binding proteins.
- 12. — Bisphosphonate that inhibits osteoclast-mediated bone resorption.
- 14. — Inhibits myocardial Na+/K+-ATPase, increasing intracellular calcium and strengthening cardiac contractility.
- 15. — HMG-CoA reductase inhibitor that reduces hepatic cholesterol synthesis.
- 16. — Activates insulin receptors, promoting cellular glucose uptake, glycogen synthesis, and lipogenesis.
- 17. — Dihydropyridine calcium-channel blocker that reduces calcium entry into vascular smooth muscle, causing vasodilation.
- 19. — Estrogen-receptor antagonist in the hypothalamus that increases GnRH, FSH, and LH secretion.
- 20. — Class III antiarrhythmic that mainly blocks potassium channels, prolonging repolarization and refractory period.
- 21. — Selective beta1-adrenergic blocker that decreases heart rate, contractility, and renin release.
- 22. — Fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication.
- 24. — Synthetic T4 that is converted to T3 and binds thyroid-hormone receptors to regulate metabolic rate.
- 26. — Glucocorticoid that suppresses inflammatory and immune gene transcription through intracellular glucocorticoid receptors.
- 28. — Inhibits vitamin K epoxide reductase, reducing synthesis of vitamin K-dependent clotting factors II, VII, IX, and X.
- 31. — Antimuscarinic that blocks muscarinic receptors in airway smooth muscle, causing bronchodilation.
- 33. — Mu-opioid receptor agonist in the gut that decreases peristalsis and intestinal secretion.
- 35. — Binds glutamate-gated chloride channels in parasites, causing paralysis and death of the organism.
Down
- 1. — Vasopressin analogue acting at V2 receptors to increase renal water reabsorption.
- 3. — Inhibits fungal CYP450-dependent lanosterol 14-alpha-demethylase, reducing ergosterol synthesis.
- 4. — Dopamine D2-receptor antagonist and 5-HT4 agonist that enhances upper GI motility and has antiemetic effects.
- 5. — Directly relaxes arteriolar smooth muscle, lowering peripheral vascular resistance and blood pressure.
- 8. — Aldosterone-receptor antagonist in the distal nephron, promoting sodium/water loss while sparing potassium.
- 9. — Nitrate that releases nitric oxide, increasing cGMP and dilating veins and coronary arteries.
- 11. — Irreversibly blocks the platelet P2Y12 ADP receptor, reducing platelet aggregation.
- 13. — Decreases hepatic glucose production, increases insulin sensitivity, and activates AMPK.
- 18. — Recombinant erythropoietin that stimulates erythroid progenitor proliferation and red-blood-cell production.
- 23. — Angiotensin II receptor blocker that prevents angiotensin II from binding AT1 receptors.
- 25. — H2-receptor antagonist that reduces histamine-stimulated gastric acid secretion.
- 27. — ACE inhibitor that prevents conversion of angiotensin I to angiotensin II, lowering aldosterone and blood pressure.
- 29. — Guanosine analogue phosphorylated by viral thymidine kinase; inhibits viral DNA polymerase.
- 30. — Irreversibly inhibits cyclooxygenase-1, reducing thromboxane A2-mediated platelet aggregation.
- 32. — Proton-pump inhibitor that irreversibly blocks the gastric parietal-cell H+/K+-ATPase.
- 34. — Selective beta2-adrenergic agonist that increases cAMP and relaxes bronchial smooth muscle.