6605.4 Lab 1

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Across
  1. 1. The fusion protein created in t(9;22) results in BLANK cell growth.
  2. 3. The fusion protein created in t(9;22) decreases BLANK BLANK.
  3. 4. This disease results in excessive scar tissue in bone marrow.
  4. 7. This is fused in a t(9;22)
  5. 8. ABL normally promotes this. (two words)
  6. 11. CML, Polycythermia vera, essential thrombocythemia, and myelofibrosis are all examples of these (2 words).
  7. 13. This type of cancer originates in bone marrow stem cells.
  8. 15. Enlargement of the spleen.
  9. 16. BCR is normally involved in this. (two words)
Down
  1. 1. The fusion protein created in t(9;22) results in BLANK of apoptosis.
  2. 2. This disease results in overproduction of platelets (2 words).
  3. 5. This type of FISH probe is used on bone marrow to detect t(9;22).
  4. 6. This chromosome is seen commonly in CML patients.
  5. 9. Jak2 is a BLANK BLANK that promotes cell growth.
  6. 10. This type of FISH probe targets locus-specific regions for a specific cancer translocation. If there is a translocation, you will get 2 translocation signals, and one signal for each normal chromosome.
  7. 12. This disease results in overproduction of rbc (2 words).
  8. 14. This type of FISH probe has 2 probes flanking a breakpoint region and are used to detect translocations.