ACO

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Across
  1. 2. Lung function test central to COPD and ACO diagnosis
  2. 5. Observable clinical cluster; three distinct ACO variants found
  3. 9. AI capability — forecasting exacerbations using real-world data
  4. 10. Inhaled corticosteroids, used cautiously in overlap phenotypes
  5. 11. Monoclonal antibody class for eosinophilic ACO
  6. 12. CT finding reduced in ACO vs pure COPD
  7. 13. Acute worsening event now predictable by AI models
  8. 14. Global Initiative for Asthma — GOLD's partner in jointly redefining ACO framework
Down
  1. 1. Measurable indicator guiding ACO diagnosis and treatment
  2. 3. Co-existence of asthma and COPD features
  3. 4. Global Initiative for Chronic Obstructive Lung Disease — co-author of 2025–26 joint statement
  4. 6. Elevated blood count driving biologic selection in T2 ACO
  5. 7. Medicine paradigm using biomarkers to tailor therapy
  6. 8. Disease subtype defined by biological mechanism