Actin, Dystrophin, and Skeletal Muscle

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Across
  1. 4. in this kind of dystrophy, functional dystrophin is completely absent in from the skeletal muscle
  2. 5. a form of RNA splicing which results in a truncated but functional protein; restores the open reading frame
  3. 6. in this kind of muscular dystrophy, there is not enough dystrophin expression for full muscular function
  4. 7. dystrophin-positive muscle fibers in some patients with DMD
  5. 10. structural unit of a myofibril, composed of the contractile proteins actin and myosin
  6. 11. the creation of the mature mRNA transcript
  7. 12. this kind of mutation is found in 60% of BMD and DMD patients
  8. 13. long, cylindrical structures that make up muscle fibers
Down
  1. 1. this method uses antibodies to detect antigens in cell samples
  2. 2. the span of DNA between a start and stop codon
  3. 3. old name for the dystrophin gene (now known as DMD) located at the XP21 locus on the X chromosome
  4. 8. its filaments are found in the cytoskeleton and in muscle fibrils
  5. 9. this protein connects the cytoskeleton to the extracellular matrix by binding actin