Across
- 2. Uncontrolled cell division can lead to _________.
- 4. Proto-oncogenes mutate to form what?
- 5. What do active cyclin-CDK complexes do to proteins that help regulate progression through the cycle?
- 8. Cell death is also known as ____________.
- 10. Which cyclin-CDK complex inhibits Rb proteins?
- 12. When Rb is activated, it binds to ___________ factors.
- 14. Active p53 does what to the cell cycle?
- 16. In early G1 phase, Rb is active and ____________.
Down
- 1. Cyclins present in G1 allow what to occur?
- 3. What is found at different stages of the cell cycle to ensure the process proceeds in the correct order?
- 6. Cylin, retinoblastoma and p53 are all examples of what?
- 7. An uncontrolled reduction in the rate of the cell cycle can lead to _____________ diseases.
- 9. Active retinoblastoma __________ cell cycle progression.
- 11. What proteins activate p53?
- 13. Cyclins bind with and activate __________.
- 15. Rb are considered _________ suppressor proteins.
- 17. Which protein is activated when DNA is damaged?
