Across
- 4. CK elevation
- 6. Side effects are progressive multifocal leukoencephalopathy and Hep B reactivation
- 8. MOA poly ADP ribose polymerase inhibitor
- 11. separate doses by by a minimum of 72 hours
- 13. Side effect GI perforation
- 15. monitor fasting glucose and lipids
- 17. use caution with strong CYP 3A4 inhibitors and inducers
- 19. Must use a condom
- 22. Contraindicated when bilirubin >1.5 x ULN
- 24. side effect herpes infections (cold sores)
Down
- 1. highly protein bound 99%
- 2. Binds to BCR-ABL to prevent unregulated cell growth
- 3. side effects cough and pulmonary embolism
- 5. ppi and H2 decrease absorption
- 7. reduce in renal impairment CrCl 20-39ml/min
- 9. Mtor inhibitor
- 10. pregnancy test prior to tx
- 12. capillary leak syndrome
- 14. Irreversible inhibitor of 20s proteasome
- 16. monitor QT interval prior to tx
- 18. monitor vital signs up to 1 hours after infusion
- 20. side effect musculoskeletal pain
- 21. CDK 4 and 6 inhibitor MOA
- 23. side effect is GI perforation